Journal: Biosensors

Article Title: Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips

doi: 10.3390/bios12090681

Figure Lengend Snippet: Schematic view of the microfluidic chip for the dielectrophoretic deposition of CTCs on the surface of the SERS platform ( a ), cross-section of the chip before assembly ( b1 ) and after placing cover plate on the top plate ( b2 ), detailed view of the microfluidic chamber with the DEP electrode under the SERS platform and counter-electrode at the top of the chamber ( c ).

Article Snippet: For this reason, a 2D numerical model of the dielectrophoretic chamber and SERS platform was developed in COMSOL Multiphysics 5.4a.

Techniques:

Journal: Biosensors

Article Title: Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips

doi: 10.3390/bios12090681

Figure Lengend Snippet: Bottom plate of the microfluidic chip for the dielectrophoretic deposition of CTCs with the SERS platform at the very center and chamber for the DEP counter-electrode and sealing ( a ); bottom plate with the DEP electrode closed with a top plate and assembled with four M3 bolts ( b ); view of the assembled microfluidic chip with a connected signal generator and PE tubing running to a syringe pump ( c ).

Article Snippet: For this reason, a 2D numerical model of the dielectrophoretic chamber and SERS platform was developed in COMSOL Multiphysics 5.4a.

Techniques:

Journal: Biosensors

Article Title: Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips

doi: 10.3390/bios12090681

Figure Lengend Snippet: ( A ) The experimental setup for deposition of CTCs on SERS platform: the AC electric filed is generated by a function generator (a), monitored with a digital oscilloscope (b) and applied to DEP electrode and counter-electrode, which are a part of the microfluidic platform (d). CTCs can be introduced into microfluidic platform via the syringe pump and PE tubing (c). The microfluidic platform in not at scale. ( B ) The experimental setup used for dielectrophoretic deposition of CTCs on the SERS platform. The DEP chip in placed on a 6-arm PCB holder. The DEP electrodes are connected to a signal generator (a) and digital oscilloscope (b). CTCs are introduced to microfluidic chip (d) via the syringe pump (c).

Article Snippet: For this reason, a 2D numerical model of the dielectrophoretic chamber and SERS platform was developed in COMSOL Multiphysics 5.4a.

Techniques: Generated

Journal: Biosensors

Article Title: Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips

doi: 10.3390/bios12090681

Figure Lengend Snippet: DEP electrode placed from the bottom of the SERS platform. The small diameter (5 μm in comparison to the diameter of the needle at 260 μm) results in a high electric-field gradient, which is required for effective dielectrophoretic deposition of the CTCs. ( a ) the general SEM view of the needle, ( b ) higher magnification with marked diameter of the end of the needle.

Article Snippet: For this reason, a 2D numerical model of the dielectrophoretic chamber and SERS platform was developed in COMSOL Multiphysics 5.4a.

Techniques: Comparison

Journal: Biosensors

Article Title: Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips

doi: 10.3390/bios12090681

Figure Lengend Snippet: The SERS spectra of ( A ) MCF−7 and ( B ) MDA−MD−231 recorded in the pDEP−SERS device without (a) and with (b) the application of dielectrophoretic trapping of CTCs. The corresponding SEM images of ( C ) the MCF−7 and ( D ) MDA−MD−231 deposited on the surface of the SERS platform with this dielectrophoretic effect.

Article Snippet: For this reason, a 2D numerical model of the dielectrophoretic chamber and SERS platform was developed in COMSOL Multiphysics 5.4a.

Techniques: